Influence of Formulation and Process Variables on the Formation of Rifampicin Nanoparticles by Ionic Gelation Technique
نویسندگان
چکیده
Chitosan, a natural biodegradable polymer is recommended for development of nanoparticles intended for chronic infection such as tuberculosis. Formulation and processing variables play a critical role in the formation of nanoparticles prepared with chitosan. The present study investigated the influence of polymer (chitosan) molecular weight, stabilizing agent (tween 80) concentration and stirring speed on rifampicin nanoparticles prepared by ionic gelation of chitosan with sodium tripolyphosphate. FTIR and DSC analysis revealed no chemical interaction between rifampicin and chitosan. DSC thermogram showed amorphous formation of the drug and polymer.Chitosan molecular weight, tween 80 concentration and stirring speed did not affect morphology of nanoparticles; however influenced the particle size, zeta potential, polydispersity index, drug encapsulation and loading efficiency and release of rifampicin nanoparticles. Our findings suggest that chitosan molecular weight, tween 80 concentration and stirring speed are important factors that need to be optimized to meet the desired qualities of rifampicin loaded chitosan nanoparticles.
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